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  • Nesterova A. Disease Pathways. An Atlas of Human Disease...2020
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  • Nesterova Disease Pathways Atlas Human 2020
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Textbook in PDF and DJVU formats

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.
Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.
This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.
Key Features
Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology.
Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio commercial software.
Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Readership
Endocrinologists, neurologists, cardiologists, immunologists, molecular biologists, geneticists, biochemists, students, and researchers who require information to understand cellular and molecular mechanisms of human diseases
Disease Pathways: An Atlas of Human Disease Signaling Pathways
Copyright
Contributors
Foreword: The future of medical discovery
Preface
Intended audience
Guide and legend
Introduction
Terminology of cellular systems
Signal reception
Signal transduction inside the cell
Cell response
Major signaling pathways
Diverse definitions and concepts of systems biology
Pathways as objects for analysis in systems biology
Pathways ontology and disease pathways
Reconstruction of disease pathways described in the book
References
Human disease pathways
Infectious diseases
Human immunodeficiency virus (HIV) and Łacquired immunodeficiency syndrome (AIDS)
Outcome effects
Transport to the nucleus and viral integration
Viral reproduction
Outcome effects
Signaling
Low level of viral production
Postintegration latency
References
Human T-cell leukemia virus infection and leukemia progression
Signaling
References
Human papillomavirus infection and cancer
Signaling
References
Diseases of the blood
Anemia of chronic disease (inflammatory anemia)
Signaling
References
Hemophilia
Coagulation cascade
Feedback relations between coagulation and fibrinolysis
References
Endocrine, nutritional, and metabolic diseases
Diabetes mellitus type I
Signaling
Inducing signals
Signaling
References
Type diabetes mellitus
Signaling
Insulin processing and storage
Insulin secretion
Signaling
Proliferation
Neogenesis/dedifferentiation
Recovery
Outcome effects
Inflammation-related insulin resistance
FFA-related insulin resistance
References
Diabetic neuropathy
Signaling
References
Hypothyroidism
Thyrotropin-releasing hormone
Thyroid stimulating hormone
TSHR signaling and thyroid follicle cells
Hashimoto’s thyroiditis
General pathways of thyroid hormone signaling
Cell-specific effects of thyroid hormone action
References
Alpha- antitrypsin deficiency
Signaling
References
Cystic fibrosis
Signaling
Outputs
Mucus production
Oxidative stress
References
Diseases of the nervous system
Alzheimer’s disease
Signaling
References
Amyotrophic lateral sclerosis
Signaling
References
Familial hemiplegic migraine (FHM)
NO and PGH synthesis in neuronal tissue
NO-mediated vasodilation
Outcome effects
Signaling
References
Diseases of the eye
Glaucoma
Signaling
References
Age-related macular degeneration
Signaling
References
Cataract
Signaling
References
Diseases of the ear
Hearing loss
Signaling
References
Otitis media
Signaling
References
Diseases of the circulatory system
Atherosclerosis description
Signaling
The first mechanism is NO and ROS production
The third mechanism is ECM remodeling
Signaling
References
Hypertension
Signaling
References
Pulmonary arterial hypertension
Signaling
References
Hypertrophic cardiomyopathy
Signaling
References
Arrhythmogenic right ventricular dysplasia (ARVD)
Signaling
References
Diseases of the respiratory system
Asthma
Key cellular contributors and processes
Outputs
Antigen-presenting cells in asthma
IgE antibodies production
Outcome effects
Eosinophil migration and activation
Eosinophil apoptosis
Neutrophil chemotaxis and activation
Outcome effects
Mucins release
Regulation of airway surface liquid thickness
Airway smooth muscle cell contraction
ASM proliferation and airway tissue remodeling
References
Chronic obstructive pulmonary disease
Key cellular contributors and processes
Signaling
References
Diseases of the digestive system
Crohn’s disease
Incoming signals
Signaling
References
Ulcerative colitis
Outcome effects
Cell-to-cell junctions
Short-chain fatty acids
Signaling
Polymorphisms associated with inflammatory bowel diseases
References
Celiac disease
Signaling
References
Nonalcoholic fatty liver disease
Signaling
References
Diseases of the skin and subcutaneous tissue
Acne vulgaris
Signaling
References
Atopic dermatitis
Signaling
Outcome effects
Signaling
References
Psoriasis
Signaling
References
Ichthyosis
Signaling
References
Diseases of the musculoskeletal system
Osteoarthritis
Signaling
References
Osteoporosis (type I)
Signaling
References
Osteopetrosis
Signaling
References
Diseases of the genitourinary system
Pyelonephritis
Signaling
References
Glomerulonephritis
Signaling
References
Polycystic kidney disease
Signaling
References
Polycystic ovary syndrome
Signaling
References
Endometriosis
Signaling
References
Pathway analysis perspectives/advantages
Applications of disease pathways in biology and medicine
Pathway analysis for personalized medicine
Bioinformatics foundation for patient data analysis
Gene grouping techniques
Pathway analysis as a part of functional enrichment analysis
Pathway topology–based enrichment analysis
Network-based enrichment analysis
Pathway and network analysis output interpretation
In silico modeling in biomedicine
Pathway collections and network databases
Software and tools
Conclusion
References
Glossary and index
Links
Index
Back Cover


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Nesterova A. Disease Pathways. An Atlas of Human Disease Signaling Pathways 2020.djvu 13 MB
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